It would have to be NEO since he has bullet time. Unless of course NEO was fighting outside the Matrix, and then Blade would kick his butt.
Now if it was Neo vs Bill Gates, then Bill could get his team to re-program the Matrix, then it wouldnt work properly.;D
Neo can be the one all he feckin wants but if i saw blade flying at me with one of his numerous weapons id cack it. Neo is just scrawny and overrated.
hmm... tough one, i reckon if Blade got in there quick enough and had the element of suprise, he could do it. However, Neo being all weird and bendy would probably just about do it!